Tumor Lysis Syndrome (TLS)

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Who gets it?Patients with lymphoproliferative or hematopoietic malignancy, and sometimes those with a large tumor burden. Chief complaint is vague, with weakness, anorexia, nausea, vomiting, diarrhea, seizures, and arrhythmias.

What is it? An oncologic emergency during antitumor treatment (and may also occur spontaneously).

Where do I look? Complete metabolic panel (including phosphorus, calcium, LDH, and uric acid) and EKG.

When would this happen? Anytime, including 3 days prior to or up to 7 days after initiation of chemotherapy.

Why does this happen? Lysis of malignant cells causes a massive release of intracellular material into circulation, resulting in metabolic derangements: Hyperuricemia – nucleic acids break down and become uric acid Hyperkalemia – high intracellular potassium content Hyperphosphatemia – high intracellular phosphate content HYPOcalcemia – excess phosphate binds to serum calcium, making calcium phosphate

And then what happens? Acute kidney injury from uric acid and calcium phosphate crystal deposition. Arrhythmias and neurological manifestations of electrolyte disturbances.

How is TLS treated? - IVF hydration - Management of hyperkalemia and symptomatic hypocalcemia - Allopurinol to decrease uric acid production - Rasburicase to decrease uric acid levels - Consult nephrology and oncology, consider renal replacement therapy and phosphate binders

Want to read more? http://www.emdocs.net/9077-2/ https://www.ebmedicine.net/topics.php?paction=showTopicSeg&topic_id=216&seg_id=4349 https://lifeinthefastlane.com/ccc/tumour-lysis-syndrome/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806807/

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Topical Tetracaine: To Take Home or Not?

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Hi everyone,
For today's POTD, we will be looking at the question of whether tetracaine and other topical anesthetics are safe to give patients to take home for corneal abrasions.
Conventional teaching is that while effective at reducing pain, prolonged use of topical anesthetics leads to poor wound healing of the corneal epithelium, and potential development of badness such as corneal ulcers down the line.
Where does that dogma actually come from, and does that really mean your patient's eyeball is going to melt off immediately if you slip them a bottle of tetracaine to take home?
Let's look at some cold, hard facts, courtesy of Rebel EM:

As you can see, these were all small case reports or case series. More importantly, in all but one case, the patients with adverse outcomes were abusing topical anesthetics for weeks/months, at higher concentrations than those typically used today.

In recent years, there have been a slew of newer studies from both emergency and ophthalmology literature attempting to refute this dogma. A systematic review of these studies was published in 2015 by Swaminathan et al. in JEM, titled "The Safety of Topical Anesthetics in the Treatment of Corneal Abrasions: A Review."

- This included 2 ED-based, randomized, double blind, placebo-controlled studies on human patients with corneal abrasions.

- There were also 4 studies on patients who underwent photorefractive keratectomy (PRK), an ophthalmologic procedure similar to LASIK where a corneal incision is made, kind of like a corneal abrasion.

- All 6 studies demonstrated that a short course of dilute topical anesthetic provided efficacious analgesia without adverse effects or delayed epithelial healing.

A separate observational chart review in Annals from 2017 by Waldman, et al. looked at 1576 corneal abrasions, 533 of which were simple, who were treated with topical tetracaine 1% for 24 hours.
- Simple was defined as: not large, penetrating, or lacerating, with onset within 2 days from a simple traumatic cause, excluding chemical exposure, contact lens use, infection, retained foreign body, or other contamination.
- 57% of the simple corneal abrasions were given tetracaine, and 14% of non-simple corneal abrasions also received tetracaine.
- While there were ZERO serious complications for ANY patient given 24 hr of tetracaine, the authors did find a slight increase in the number of repeat ED visits in non-simple corneal abrasion pts who were given tetracaine.
Bottom line: 
1) Short-term use of dilute topical anesthetics for simple corneal abrasions for 24-48 hrs is definitely effective and most likely safe, as shown by several recent small but well-designed randomized controlled studies.
2) The risk and safety concerns associated with the use of topical anesthetics is likely overstated, and come from poorer quality evidence such as experimental animal studies, case reports, and case series.
3) At the same time, larger studies should be undertaken to assess safety before the widespread use of this pain management modality can be recommended.
References:
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POTD- Sickle Cell

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In todays POTD were gonna talk Sickle Cell Anemia. Why? Because we don't see it very often at maimo but complications related to SCA present pretty commonly to most EDs... and because I randomly had about 10 Rosh review questions in row about it...

We all know the basics at least vaguely from step 1
  • 100,000 ppl in US, 2mi Carriers. Mc African, Mediterranean, Indian and Middle Eastern
  • AR exchange of Valine for glutamic acid in the B global chain changing the structure so that when deoxygenated it sickles
  • Diagnosed on newborn screen or after 4mos of life (Why? because of the decline in fetal Hb)
So lets talk some of the more common presentations:
  • Remember basic workup should include CBC and retic count plus specific labs/imaging for sx..
Stroke:
  • RFs: High flow velocity on dopler, low Hb, high WBC, HTN, hx TIA, hx ACS
  • Imaging: PEDS: NEED MRI w/ diffusion as CT can miss and early infarct!
  • Trx:
    • Adult: tPA v intraaterial thrombolysis
    • Peds: IVF and exchange transfusion with goal of HgbS < 30%
      • Target MAX HG of 13 or can cause recurrent ischemia
      • 30% have hemorrhagic transformation
      • *** Control BP with labetolol to goal of 50-95th% for age
Acute Chest Syndrome:
  • Fever, cough cp, hemptysis , dyspnea
  • CXR: new infiltrate
  • Some Guidelines:
    • All pts should be hospitalized for pain control and monitoring
    • Trx with IV cephalosporin + oral macrolide
    • Goal O2 >95%
    • Transfuse if Hb is >1g/dL below baseline
    • Higher mortality in adults so should go to ICU as can progress to ARDS
Pain: The somewhat dreaded hard to control complain,
1st and foremost be sympathetic and treat accordingly, they often have their own pain plans and can provide some insight into what works.
  • Think about these dangerous causes and don't just dismiss as "drug seeker"
    • CP: Think ACS v ARDS Vhighoutpt heart failure v PNA v pain crisis
    • HA: Think stroke v meningitis v CVST v ocular pathology
    • Arthralgias: Septic arthritis v actor trauma v avascular necrosis
    • Abd Pain: Splenic sequestration v acute intrahepatic sequestration v pain crisis 2/2 occlusion of mesentery v renal infarct
  • Treating Pain:
    • Should get analgesia w/in 30min of arrival
    • Use NSAIDs as adjunct
    • Follow pts pain plan if available
    • Avoide Meperidine
Fever:
  • MCC? Viral, But always think of the encapsulated organisms (S pneumonia, HiB, non-typhi Salmonella, Mycoplamsa, C. Pneumonia, Yersinia) which are higher risk in these pts d/t functional asplenia
  • Prophylactic PCN for pts 2mo-5years- check compliance, PCV at 2mos, Influenza vaccine at 6mos
    • Bactermia, Pneumonia--> S pneumonia
    • UTI--> EColi
    • Osteo--> Salmonella
    • TRX: Ceftriaxone +Vanco
  • Some great guidelines from CHOP for pediatric fever: http://www.chop.edu/clinical-pathway/sickle-cell-disease-with-fever-clinical-pathway
A couple others...
RUQ pain: Acute chole v cholelithiasis v acute intrahepatic cholestasis v acute sickle hepatic crisis v acute hepatic sequestration
  • CBC, LFTs, Coags, imaging- CT v US
  • Trx of AHS is simple v exchange transfusion
Splenic Sequestration:
  • Acute drop in hgb >2, splenomegaly, reticulosytosis, intrascaular volume depletion
  • Rapid progress to shock and death
  • MC kids 10-27 mos old
  • IVF + transfusion ( simple v exchange)
and don't forget the beloved board question... Aplastic Crisis... from what Parvovirus B19
  • Pallor, tachycardia, supportive care unless retic < 1-2 then simple transfusion.
A great summary chart!

AND FINALLY... When to transfuse:
Sources:
JAMA 2014 Sep- Manamge of SCD: summary of the 2014 evidence-based report by expert panel members.  https://www.ncbi.nlm.nih.gov/pubmed/25203083
EMDocs
CHOP clinical guidelines
RoshReview
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