POTD: Burn

Today we'll go in the opposite direction of frostbite and talk about burns. While Maimonides is not a burn center, we still do get burn patients coming in. 

Classifying Burns:

We no longer use 1st, 2nd or 3rd degree but based this off the depth of the burn

Superficial thickness: involves the epidermal layer only

Skin looks red

Superficial partial thickness:  involves the superficial dermis. 

Can cause blisters, looks wet, more painful

Deep partial thickness: involves the deep dermis

Looks cherry red or pale, now causing delayed cap refill

might be less painful now

Full thickness: Involves all the layers including fascia, muscle, bone

looks white, waxy, leathery. No cap refill

usually painless in that area

Burns can worsen over time and the full extent may not be known immediately

Estimating Burn size:

Only include partial and full thickness used to estimate seize. 

Rule of 9's and the Palmar Method are two ways to estimate the size of the burn


Wound Care:

Run wound under cold water if possible and you can use soap to clean it. Avoid ice or toothpaste as this may worsen the injury.

Keep the wound moist to aid in healing and use a non-adherent pad 

Silver Sulfadiazine used to be recommended but may actually slow healing so no longer recommended. Bacitracin can be used for superficial wounds. 

Blisters: sloughed, necrotic or ruptured blisters can be debrided but otherwise small unruptured blisters should be left alone. 

Airway Considerations:

Keep a high suspicion for impending airway compromise. There may be inhalation injury. 

Signs for early intubation include: respiratory distress, stridor, hoarseness, burns to the face and neck, blisters in the oral mucosa

You can also consider using a scope to visualize patient's supraglottic area to see if there is edema, erythema

Indications for ED Escharotomy:

Escharotomies in burn patients are considered when the injury is extensive enough to cause compartment syndrome

Indications include: 

Inability to ventilate patient due to burns to the torso, absent or decreasing pulses, neuro deficits

Escharotomy is done to the burn areas with eschar and not to the fascial layers like a fasciotomy


Fluid Resuscitation:

These patients have impaired skin barriers and are likely to be dehydrated and it is important to fluid resuscitate them

Parkland Formula is widely used to calculate the amount of fluids to give to these patients. However there is concern of causing fluid overload and edema. 

The Modified Brooke's can be used and this allows for less initial fluids to be given to hopefully prevent fluid overload. 

Infection: 

These patients are at higher risk for infection. However, the use of prophylactic antibiotics is controversial. 

Antibiotics should be given when there is proven infection or the patient is septic. 

Indications for transfer:

Full thickness burns

Partial thickness and >/= 10% TBSA

Partial or full thickness involving hands/feet, face, genitals, over joints

Burns with other traumatic injuries

Uncontrolled Pain

Inhalation injury

Chemical Injuries

High Voltage Injuries (>1000)

Lightning Injury


POTD: Frostbite

Stepping outside and feeling the frosty air helped me pick the topic for today: Frost bite!

Frost bite is a cold injury when ice crystal formation intracellularly and extracellularly cause cell injury and death leading to tissue injury. 

Pathophysiology: 

At first the cold causes cell death with ice crystal formation. Then once thawing begins, there is a lot of inflammation, vasoconstriction of vessels, thrombus formation and emboli in small vessels. This causes more ischemia, cell death and leads to necrosis. 

There are different ways to classify frostbite with Cauchy et. al’s used the most. This grading is done after rewarming because it can be hard to tell the extent of injury beforehand. 

Upper and lower extremities are most commonly affected but frostbite can also occur on other exposed skin such as the nose or ears. 

 

Before arrival to the ED, do not start rewarming!

Refreezing of thawing tissue worsens the damage being done. 

First Steps when someone arrives to the ED with frostbite:

Remove wet clothes

First step is to assess for hypothermia and treat moderate to severe hypothermia first. 

Next will be to warm the affected area: 

Keep in mind this can be very painful!

Rewarm the area with water that is around 37-39 degrees celsius. Ideally the water should be circulating like in a whirlpool. 

I don’t think we have this available in the ED but you can consider if it’s a hand having your patient by the sink and keeping the water running.

Patient should be directed to slowly move the extremity

This treatment should continue until tissue is red, purple or soft (about 15-30 minutes)

Provide TDAP

Treatment:
* Of note, while Iloprost has been approved in the US it is not available for use. Further research also needs to be done to determine if it is beneficial over just using thrombolytics

  • If Grade 1 frostbite, Frozen > 24 hrs, Thawed > 72 hrs, freeze-thaw-refreeze

    • wound management is what can be offered

  • If the frost bite is grade 3 or 4 

    • If thawed < 24hrs, 

      • thrombolytics can be considered after reviewing contraindications

    • If thawed > 24 hrs, 

      • Cannot give thrombolytics

    • If thrombolytics can be given do that first, then for these grades you can give Iloprost IV infusion for 8 days

  • If Grade 2 or 3

    • Can offer patient 8 day hospital stay for Iloprost infusion

TLDR:

  • Do not rewarm if there's a chance of the injury refreezing

  • Treat moderate and severe hypothermia first

  • Able to grade the severity of injury after rewarming

  • Thrombolytics can be offered for grade 3 or 4 if thawed < 24hrs

  • Iloprost can be offered after thrombolytics, if grade 3 or 4, or even if grade 2 or 3.

  • Wound care management for everyone

  • TDAP

Iloprost is associated with lower amputation rates but further research still needs to be done. 



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POTD: Sedation meds for agitated patients

POV you’re on south and a patient in chairs wakes up and starts running around the doc box yelling and throwing their apple sauce everywhere. Security and psychiatry are no where to be found and you already attempted to verbally deescalate.

ED sedation is goal-directed, not one-size-fits-all. Medication choice should be based on the clinical goal (calm vs dissociate vs procedural), patient physiology, and airway risk. Rapid control of severe agitation is critical for the safety of the patient, staff, and surrounding patients.

Ketamine

Indications: Severe agitation, excited delirium, trauma, need to preserve airway reflexes

IV: 0.5–1 mg/kg (procedural: 1–2 mg/kg)
IM: 3–5 mg/kg
Onset: IV 1–2 min | IM 3–5 min
Pearls: Dissociation + analgesia
Watch for: Hypersalivation, vomiting, emergence reactions
Tip: Position upright when feasible to reduce aspiration risk

Midazolam

Indications: Anxiolysis, mild–moderate agitation, alcohol withdrawal
IV: 1–2 mg q2–5 min (usual max 5 mg)
IM: 5 mg
IN: 0.2 mg/kg (max 10 mg)
Onset: IV 2–3 min | IM 10–15 min | IN 5–10 min
Watch for: Respiratory depression especially with opioids or alcohol, avoid in elderly patients

Haloperidol

Indications: Psychosis-related agitation
IV/IM: 2.5–5 mg (may repeat; typical max 10 mg)
Onset: IV 5–10 min | IM 20–30 min
Pearls: Minimal respiratory depression
Watch for: QT prolongation, dystonia 

Droperidol

Indications: Acute agitation
IV/IM: 2.5–5 mg
Onset: IV 5 min | IM 5–10 min
Pearls: Rapid, reliable calming
Watch for: QT prolongation (risk low at ED doses)

Olanzapine

Indications: Agitation related to psychosis, bipolar disorder, delirium
IM: 5–10 mg (max 20 mg/day)
PO/ODT: 5–10 mg
Onset: IM 15–30 min | PO/ODT 30–60 min
Pearls: Effective calming with low EPS risk

Dexmedetomidine

Indications: Cooperative sedation, ICU-bound agitation
IV infusion: 0.2–0.7 mcg/kg/hr
Onset: 10–20 min
Pearls: Preserves respiratory drive
Watch for: Bradycardia, hypotension

Propofol

Indications: Procedural sedation (full monitoring and airway readiness required)
IV: 0.5–1 mg/kg bolus, then 10–20 mg PRN
Onset: 30–60 seconds
Pearls: Rapid on/off
Watch for: Hypotension, apnea

The classic haloperidol 5 mg + lorazepam 2 mg works- however, evidence suggests faster alternatives exist with similar or better safety profile including:

  • Droperidol 5 mg + midazolam 5 mg IM, or 

  • Ketamine when safety concerns are immediate

https://www.acepnow.com/article/which-sedatives-are-best-for-managing-severe-agitation-in-the-emergency-department/?singlepage=1

https://pubmed.ncbi.nlm.nih.gov/34353650/

https://www.ncbi.nlm.nih.gov/books/NBK551685/

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