POTD: Potpourri (LLFTP #9)

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Welcome to my final POTD of this block, and the 9th installment of “Lessons Learned from The Pitt”. Rather than focus on a singular case, I’ll end with a potpourri. 

Spoilers and anguish ahead.

It is now 3pm at this ED, and the ratio of “things happening” to “time elapsed” continues to steadily increase. When the episode begins with an interrupted debrief for poor drowned Amber, followed by shots of much of the cast going through their own trauma responses (Dr. Langdon calling home, so he can hear his son’s voice, just hits different), you know that things are probably going to keep going downhill. The purpose of a debrief is to give the team a little time and space to process and recontextualize the events, identify areas of improvement within a supportive learning environment, and assess the need for further support (such as a Team Lavender consult). The facilitator (usually the attending, or other designated staff member) will gather the team members, establish that the debrief is intended to be a safe space, establish the above objectives, and then step back and nudge the conversation as needed. One of the staff (usually the team leader) will summarize the events that occurred; the rest should hit upon three areas — the “plus”, the “delta”, and the “take home”; respectively, those are the things that were done well, opportunities to improve, and learning/action items. If an official Clinical Event Debriefing form is submitted, there is an ED leadership team that will discuss those points in a biweekly meeting and try to address said action items. 

Back to the episode. With 4 hours left in the shift officially (though we all know that there are 15 episodes, so something’s coming), people start to hit their breaking points. The first two are on the patient side, and both occur in the packed-like-sardines waiting room. Mr. Driscoll, the chest pain patient who has become progressively more frustrated, hostile, and racist with each episode he continues to remain in the waiting room, finally decides he’s had enough and starts leaving after a tirade. Dr. Langdon calls Driscoll out over the speaker to tell him that he would be departing “Against Medical Advice”, with risks including dropping dead from a heart attack.

The AMA conversation is important when it comes to patient safety, as well as one’s own medicolegal protection (patients who leave AMA are more likely to have a bad outcome and more likely to sue). Patient autonomy is one of the ethical cornerstones of modern medicine, and restricting an individual’s freedom of movement without justifiable cause constitutes the crime of false imprisonment — thus, (most) patients cannot be physically stopped from leaving unless they are obviously impaired/dangerous. Ideally, before that happens, the treating physician is able to have a conversation with the patient; the discussion should allow the physician to assess the patient’s capacity to make this decision (briefly, displays understanding of their current condition, demonstrates insight into the benefits of staying vs the risks of departing including specific risks incurred by the suspected disease processes, and is able to articulate an intact thought process i.e. intact judgment regarding how they came to their decision), and then take steps to mitigate harms (such as giving prescription antibiotics, outpatient follow-up, et al.). The AMA discussion also may be the last opportunity for “service recovery”, a concept from the Patient Experience world; this can be an acknowledgement of the patient’s concerns, followed by explanations of what has happened and what can be done to improve. In this case, Mr. Driscoll has actually received a workup despite being in the ED; he’s had an ECG and troponin (plus other basic labs), with repeat troponin pending — and I don’t think anyone’s had the headspace to have an actual discussion about the plan and address his concerns with an empathetic veneer. 

The second waiting-room blowup is a fight between two women, instigated by one of them taking offense at being offered a mask for her coughing child, which charge nurse Dana steps into and ends with a dressing-down worthy of a standing ovation. This isn’t the time or place for a deep dive into the politics of masking, I’ll just say that droplet precautions were definitely around before 2020. The medical lesson here comes from the “fight bite” from our anti-mask perpetrator, who now has a tooth fragment lodged in her knuckle. Evaluation of such an injury should include assessment of the integrity of the joint capsule, of tendon involvement, of potential fractures, and of signs of infection (especially if presentation is delayed). Lacerations over the dorsal MCP joint should prompt a specific question about fights, as patients can sometimes be reluctant to divulge (they don’t know about the risk of severe infection leading to amputation). Treatment for the uninfected-appearing acute “fight bite” with no joint/tendon/bone involvement is copious irrigation, prophylactic antibiotics (usually augmentin 875mg/125mg PO BID x 7 days), +/- TDAP, healing by secondary intention, and close follow-up. Hand surgery should be consulted (and IV antibiotics considered) for signs of infection (usually with delayed presentation) especially if there is reason to suspect joint/tendon compromise. 

Back to the resus bay, another critical patient from this episode has hyperthermia and altered mental status in the context of MDMA abuse at a music festival. Her core temperature is 107 degrees, prompting the team to begin active cooling with ice-water immersion (with goal temp of 102 to prevent overshot hypothermia), as well as high-dose benzodiazepines (to oppose the centrally-mediated MDMA-induced component of her hyperthermia, as well as to prevent shivering). Later, when the patient begins seizing, Dr. Santos suggests that the patient has hyponatremia secondary to dehydration, orders 100mL of 3% saline (would raise serum Na by 2-3, usually given x3 to achieve effect), and goes above Dr. Mohan’s head to push the saline (100ml should be given over 10-15 minutes, not a 3-second push) (can also consider 1 amp of 8.4% sodium bicarb, which is in code carts and more readily available). The seizure terminates, and it’s the first resus win for Dr. Santos until Dr. Langdon returns furious and demands to know why no one bothered to come tell him about the seizure. Dr. Mohan freezes like a deer in headlights, and Dr. Santos throws herself under the bus and gives Dr. Mohan the credit for the save — prompting Dr. Langdon to go off on her, full-on shouting at her and berating her until Dr. Robby interrupts him. This is not how one should approach giving feedback to a learner — not in public, and not with such vitriol. The goal should be to communicate areas of improvement and concrete changes that can be made. If the learner has demonstrated a problematic pattern of behavior, pull them aside and address it before it becomes such an issue that you feel the need to scream at them. And if problems persist, there are people (i.e. attendings, charge nurses) to whom one can escalate.

Though Dr. Robby's response with Dr. Langdon is also not totally appropriate, shouting at him to “shut the f*ck up” when Langdon rushes to explain himself, and dressing him down in full earshot of the rest of the ED.

The episode ends with a sucker punch, delivered by a departing Mr. Driscoll to charge nurse Dana while she's stepped outside for a break. Violence against healthcare workers is a serious problem that often goes unreported or unprosecuted. Healthcare and social services workers are at the highest risk of workplace violence compared to all other civilian industries, with over a quarter of all workers facing victimization during their career. Reasons include perceptions that this is “all part of the job”, or that patients/families should be given passes due to their stress, or that they'll face censure for speaking up. Solutions include building a culture of safety and developing institutional policies. In the acute setting, early retreat and involvement of security are the best ways to protect oneself.

That's all from me today. I hope you've enjoyed this series because I've certainly had a blast writing each one! 

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POTD: Heavy Metals (LLFTP #8)

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Today's POTD will be based on the continuation of one of the cases I mentioned in my previous email. 

Spoilers?

I originally wanted to talk about Latrodectus (Black Widow) envenomation (a patient with Crohn's disease presented with isolated severe abdominal cramping, without any fever or other GI symptoms), but Dr. Ervin already wrote a nice POTD about it back in August. 

Instead, we'll follow the conclusion of Dr. Mohan's case with the altered beauty influencer. The heavy metal panel comes back at the beginning of the episode (seriously impressive turnaround time), and the patient has a mercury level > 90 mcg/L. The ordered treatment is "chelation TID, 10 mL/kg of DMSO" (which is actually a small scripting error, as you'll see below). Done and done, and Dr. Robby gracefully takes his lumps and acknowledges that "Slo-Mo" had handled the case appropriately. 

Let's learn about mercury toxicity as well as some of the other heavy metals that love to appear in test questions! 

Mercury (Hg/Hydrargyrum)

  • 3 common forms — elemental mercury, mercury salts, and organic mercury

    • Elemental — found in devices such as thermometers; volatile and easily aerosolizes, inhalation --> pulmonary, CNS, and renal symptoms

    • Salts — found in batteries, skin cream, dental products; absorbed by GI tract and across skin --> GI and renal symptoms

    • Organic — found in paint, skin cream, fish; absorbed by GI tract and across skin --> neurological symptoms

  • Hg bonds to various functional groups on proteins, leading to widespread dysfunction

  • Hg can cause direct oxidative damage to lung/GI membranes and renal tubules

  • CNS deposition of mercury (more common in elemental and organic mercury exposure) leads to posterior encephalopathy/atrophy --> sensory neuropathies, vision changes/deficits, ataxia

  • Neurological deficits likely longstanding or permanent, especially if chronic/subacute

  • Above symptoms are fairly nonspecific, diagnosis relies on thorough history

  • Supportive care is key, chelation (compounds that bind heavy metal ions, allow excretion) can help lower Hg levels

    • Elemental/salts —  IM dimercaprol 5 mg/kg q4h x 48 hours, then 2.5 mg/kg q6h x 48 hours, then 2.5 mg/kg q12h x 7 days; PLUS PO succimer (DMSA) 10 mg/kg q8h x 5 days, then q12h x 14 days

    • Organic — only succimer (DMSA), as dimercaprol has been shown to increase neurotoxicity

    • For acute ingestions, consider GI decontamination

    • HD can be considered as part of supportive care regimen if there is significant renal impairment, but does not effectively lower Hg levels

    • Exchange transfusions trialed in past with no proven benefit

Lead (Pb/Plumbum)

  • Previously had widespread presence in paint, gasoline (and exhaust), pipes; paint and pipes in older homes continue to be a source today, despite being banned in 1978 and 1986, respectively

    • Leaded gasoline banned in the US in 1996, but fumes could still cause agricultural contamination in imports; worldwide ban achieved in 2021

    • Childhood exposure through exhaust fumes reduced the intelligence (and worsened the health) of many Americans born between the 60's and 90's; i.e. petrol company lobbying and obfuscation (lead toxicity has never been unexpected, it has an older historiography than some modern religions) robbed multiple generations

    • Other exposure sources include industrial occupations, contaminated pewter/ceramics, contaminated spices, contaminated cosmetics, alternative pseudomedical practices, lead bullets

    • Children are at higher risk — they absorb more Pb for their body weight in both ingestion and inhalation, store more Pb in metabolically-active tissue, and excrete less Pb in their urine 

  • Like mercury, lead binds many proteins and inhibits their function, especially calcium and zinc related proteins

    • High blood Pb levels can lead to acute syndrome of lead-induced encephalopathy from cerebral edema --> AMS, seizures, coma, death

    • Chronic toxicity harms neurocognitive development, inhibits RBC production and maintenance ("basophilic stippling" on smear), dysregulates proximal renal tubule function, and impairs sex, growth, and thyroid hormones

  •  Nonspecific multisystemic symptoms, usually at Pb > 10mcg/dL

    • "Asymptomatic" children at risk for IQ loss (highest rate of IQ decrease is at 1 to 10mcg/dL)

    • Children may display irritability, constipation, and/or anorexia 

    • Adults may also have cardiovascular disease, peripheral neuropathy, gout, infertility

    • Levels >70mcg/dL have high risk for lead encephalopathy

  • Careful history is once again key to the path to diagnosis

  • Care is centered around screening and decontamination

    • All children with Medicaid are screened at 12 and 24 months (5mcg/dL is threshold for further testing)

    • All children recommended to be screened by age 3-5 

    • Supportive care (including supplementation with iron, zinc, and calcium)

    • Chelation indicated for levels of >45mcg/dL in children, >70mcg/dL in adults, or any patient with encephalopathy

      • BAL (dimercaprol) + calcium disodium EDTA is most common regimen, +/- succimer

      • Chelation may increase release of Pb from bones, leading to temporary exacerbation of symptoms

    • Developmental deficits from chronic toxicity likely to remain permanent

    • Permanent neurological sequelae from lead encephalopathy also likely 

Iron (Fe/Ferrum)

  • Easily available as an OTC dietary supplement, ingestion of such is the primary exposure

    • 325mg ferrous sulfate contains 65mg elemental iron

    • 300mg ferrous gluconate contains 36mg elemental iron

    • 100mg ferrous fumarate contains 33mg elemental iron

    • For prenatal vitamins and children's vitamins, check label/manufacturer's site

    • Ingestion of >20 mg/kg associated with moderate toxicity

    • Ingestion of >60 mg/kg associated with severe toxicity

  • Less commonly, iron toxicity can result from multiple transfusions for leukemia, thalassemia, etc.

  • Toxicity divided into two mechanisms

    • Caustic/corrosive effect results in direct injury to GI mucosa, can lead to perforation, peritonitis --> hemorrhage, death

      • Typically occurs during the first 6 hours

      • Iron tablets are visible on XR

    • Cellular toxicity is due to disruption of oxidative phosphorylation in the mitochondria, free radical formation and oxidative damage

      • GI symptoms may resolve prior to appearance of systemic symptoms

      • Nephropathy, cardiomyopathy, hepatopathy, and coagulopathy follow

      • Serum Fe levels >350μg/dL associated with moderate symptoms, >500μg/dL associated with severe symptoms

  • Treatment indicated for those a) with symptoms, or b) who have ingested potentially toxic quantities

    • Patients with resolved GI symptoms should continue observation/care for emergence of systemic symptoms

    • Decontamination with WBI indicated if large amount of pills are visible on XR

    • Patients with severe symptoms (acidosis, hemodynamic compromise) or high serum Fe level should receive deferoxamine chelation at 15 mg/kg/hr (max 35 mg/kg/hr) for up to 24 hours (or up to 6g)

    • Can give VitK and FFP to treat coagulopathy

    • Otherwise, supportive care as appropriate

Copper (Cu/Cuprum)

  • Exposure is most commonly from copper-containing cookware, contaminated water, or copper-containing pesticides or creams

  • Wilson's disease is also associated with high bioaccumulation of copper

  • Ingestions, like with iron, cause a direct gastropathy resulting in abdominal pain, vomiting, GI bleeding, et al. w/ potential for blue-green emesis (think how copper-containing surfaces like the Statue of Liberty develop verdigris)

  • High serum levels of copper can lead to:

    • Neuro — cognitive changes, encephalopathy

    • Cardiac — cardiomyopathy

    • Hepatic — necrosis

    • Heme — coagulopathy, hemolysis, methemoglobinemia 

    • Renal — rhabdomyolysis, AKI

  • Treatment, again, is mostly supportive + decon/chelation

    • High-dose zinc can help lower GI absorption 

    • Classically, D-penicillamine is the chelating agent of choice, given at a starting dose of 750mg QID

    • Can also use "single pass albumin dialysis" vs other extracorporeal cupriuresis

    • Symptoms generally reversible with successful elimination of copper

Other little lessons from episode #8:

  • If you have a backyard pool, invest in locked rigid covers and alarms, because otherwise the kids will find a way to get in

  • You're not dead until you're warm and dead — unless you're in rigor mortis, have obvious traumatic injuries incompatible with life, have snow in your airway after being buried by snow, or have a K > 12

  • If you lose any part of your body, to maximize the chances of replantation, you or someone else (if you're unstable) should retrieve it, wrap it in a moist towel/napkin/cloth, place it in a plastic bag, then put that plastic bag on ice

  • Peter Safar, the University of Pittsburgh, and the Freedom House Ambulance Service are the progenitors of the modern EMS model — a public service staffed by trained personnel tthat can provide care en route to the hospital, as opposed to a taxi service

  • Have a high index of suspicion for human trafficking (and/or other forms of abuse) when the patient is accompanied by someone who answers questions for them and refuses to allow a private history/exam; do your best to finagle a private conversation and assess safety, and consult social work to help provide resources if needed

References:
https://www.ncbi.nlm.nih.gov/books/NBK560920/
https://www.ncbi.nlm.nih.gov/books/NBK499935/
https://www.ncbi.nlm.nih.gov/books/NBK541097/
https://www.ncbi.nlm.nih.gov/books/NBK459224/
https://www.ncbi.nlm.nih.gov/books/NBK557456/

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POTD: Mandated Reporters (LLFTP #7)

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We're back to our regular installments of "Lesson Learned From The Pitt", now covering episode 7 as we slowly catch up to the releases. 

Spoilers, oh boy are there spoilers. Here's a link to a quick reference guide for the TL;DR crowd. 

And a trigger warning for allegations of CSA.

To me, episode 7 is where the Grey's Anatomy-esque drama really starts to kick off. We've been seeing signs of various teakettles slowly reaching their boiling points across the first third of the season, and the first to boil over is — unsurprisingly — the man who's been crushed by a multiple days' worth of critical patients in a single morning, while juggling patient satisfaction concerns, while dealing with increasingly-frequent PTSD flashbacks. When Whitaker eats lunch at a desk, he tells him off for not eating in the lounge (and for spilling a boatload of crumbs on the workstation, get that boy a SLP evaluation!) while also implying that it's too busy for the student to be eating. When Dr. Mohan orders additional labs on a patient he'd medically cleared for psych evaluation (premature closure after not taking an actual history, nice!) he berates her rather than appreciate her ability to tease out highly relevant and plan-changing information in the history, with Dr. Collins being caught in the crossfire for supporting her junior. But Dr. Robby's real explosion is yet to come, so let's turn to someone else who crosses the Rubicon this episode. 

Dr. Mohan isn't the only one who's a bloodhound on tiny details — we've been seeing Dr. Santos investigate the mystery of the hard-to-open benzo vial in the background, and in this episode her vigilantism will continue. Previously, a trauma patient (s/p mechanical fall from ladder) had needed intubation and a chest tube; Dr. Santos had noticed gynecomastia (enlarged breast tissue) which could be a sign of an underlying condition like alcoholism, and decides this needs to be investigated further in the ED before she sees any new patients. On questioning the wife, we find out that she's been doping her husband's coffee with progesterone. Why? Because she suspects her husband of molesting their daughter, and wanted to "kill his libido". 

Dr. Santos appropriately brings this to the attention of Dr. Robby (hey, she does know how to escalate to the right person!), knowing that they are mandated reporters in this state. However, Dr. Robby and social worker Kiara (both heavily overworked by this point) proceed to make one of the biggest fumbles of the show so far — telling her that they cannot make a report without "proof" and that this is all speculation. That they "can't do anything" unless the daughter comes forward. They are right in that they need to report the wife for poisoning her husband, which would at least be a first step (if suboptimal) in getting an authority involved in the situation. 

Detective Santos goes around her attending and tries speaking to the daughter after a clumsy (and failed) attempt at building rapport. The daughter denies everything and is obviously uncomfortable with this conversation. And so our brilliant intern decides to take matters into her own hands, by entering the room of an intubated and vulnerable patient, confronting him, and threatening him ("blink once if you want me to let you die"). Whether Mr. Dunn is an abuser or not (at this point we only have allegations, and in America we believe in "innocent before proven guilty"), for a physician to behave in this manner is beyond the pale. Our ethical duty is to provide unbiased and professional care to everyone regardless of their standing, and certainly not to threaten a patient with prison rape or even murder (imagine being an innocent man or woman and having your doctor come into the room accusing you of heinous crimes, while you're powerless to do anything if they decide to disconnect your ventilator). Taken in context with Dr. Santos's pattern of reckless behavior and disregard for others, I can only hope that the trauma bay is recorded (like ours) and this leads to disciplinary action. 

What should Dr. Santos have done?

She's absolutely right about being a mandated reporter. In both PA and NY law, most professions that come into contact with vulnerable populations (such as children) fall into that category. The threshold to make a report is not "we need proof", it's "reasonable cause to suspect". PA law clearly states that a specific disclosure by a third party to a mandated reporter that an identifiable child is the victim of child abuse meets that standard; that the accuser is the alleged victim's other parent heightens the need to make a report. NY law, which is what matters for us, specifies that a report should be made "when they have reasonable  cause  to  suspect that  a  child  coming  before  them  in  their professional or official capacity is an abused or maltreated child, or when they have reasonable cause to suspect that a child is an abused or maltreated child where the parent, guardian, custodian or other person legally responsible for such child  comes  before them in their professional or official capacity and states from personal knowledge facts, conditions or circumstances which, if correct, would render the child an abused or maltreated child". #Believe when it comes to the threshold for making a report. Let the police do the investigation.

Both PA and NY have hotlines for mandated reporters to make reports. In New York, we can call the State Central Register Mandated Reporter hotline directly at (800) 635-1522. Reports can also be made anonymously at (800) 342-3720. For mandatory reports, a written report must be made and sent within 48 hours of the call. Reports are confidential. One does not need the approval of a supervisor to make reports. One cannot be held liable for good faith reports. One is theoretically shielded from backlash/retributions from making reports. Not reporting when you have reasonable suspicion is a thoughtcrime for which one can be hit with a Class A misdemeanor. PA offers similar protections as NY, and even harsher penalties for failure to report (up to a 2nd degree felony). 

It's hard for someone, especially a transitional year intern, to gainsay the attending. But would you be willing to commit a crime for the attending? We already know Dr. Santos is willing to commit crimes for herself :D

Other little lessons from episode 7:

  • To quote Dr. Collins, "leave your baggage at the door like everyone else". An impaired physician, nurse, paramedic, etc. is a terrible thing for a patient. 

  • Dr. King demonstrated an excellent conversational approach to patients with autism spectrum disorder. She minimized distractions by closing the doors, shutting off alarms, and turning down the lights. She invited the patient to speak about their concerns and verbalized empathic statements. She was patient with her clarifications. She took time to explain the diagnosis at the patient's level of understanding. Note that these are things that can be done with all patients to improve their experience. 

  • During a cardiac arrest code, the team attempts double sequential defibrillation for refractory v-fib. The 1st shock theoretically potentiates the effect of the 2nd. Unfortunately, meta-analyses have found no overall benefit to v-fib termination (or survival), and it is not recommended by the AHA for routine use.   

  • For that same code, the team activates their ECMO team. Extra-Corporeal Membrane Oxygenation is a technology that oxygenates a patient's blood outside the body and then returns it, analogous to hemodialysis. Broadly-speaking, it is indicated for acute cardiac or pulmonary failure that is potentially reversible, has failed conventional treatment, and carries a high risk of death. In-hospital cardiac arrest is an example of a condition that has a decent chance (~30%) of survival with ECMO.

References:
https://www.pa.gov/content/dam/copapwp-pagov/en/dhs/documents/keepkidssafe/clearances/documents/FAQ_Mandated%20Reporter.pdf
https://www.nyc.gov/site/acs/child-welfare/mandated-reporters.page
https://www.nysmandatedreporter.org/SocialServiceLaw.aspx|
https://www.ncbi.nlm.nih.gov/books/NBK544231/
https://www.ahajournals.org/doi/10.1161/res.135.suppl_1.Mo035
https://pmc.ncbi.nlm.nih.gov/articles/PMC7867121/

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